Endocrine Abstracts

Transsphenoidal surgery still appears to be the best option for most of the patients with GH secreting adenomas. In many cases the biochemical cure targets are not reached and the patient needs adjuvant therapy. Alternatives include medical therapy with somatostatin analogues, GH-receptor antagonists and dopamine agonists. These drugs can be used alone or in combination. Radiation therapy with conventional fractionated photons or radiosurgery with proton beam could also be eff...

Introduction: Growth hormone (rhGH) is an effective treatment for short children born small for gestational age (SGA) who fail to demonstrate catch-up growth by 2–4 years of age. This children usually do not have classical GH deficiency, but either low GH secretion or reduced sensitivity to GH. The goals of therapy are to achieve a normal height in early childhood and an adult height within the normal target range.Objectives: Evaluation of efficacit...